EFSD/Lilly European Diabetes Research Programme

2016

Fredrik Bäckhed: University of Gothenburg - Sweden
Effects of sleeve gastrectomy on gut microbiota and the impact on host metabolism following surgery

Amélie Bonnefond: Pasteur Institute of Lille - France
Role of MRAP2 in pancreatic beta cells: characterisation of mutations and mechanisms linking obesity and diabetes

Caroline Bonner: University of Lille - France
Combination of low dose sulfonylureas with the SGLT2 inhibitor dapagliflozin to improve glycaemic control

Natalie Gardiner: University of Manchester - UK
Understanding how dysregulation of the skin microenvironment contributes to diabetic neuropathy

Jens Juul Holst: University of Copenhagen - Denmark
Elucidation of the physiology and pathophysiology of GIP by receptor antagonism in humans

Michal Marzec: University of Copenhagen - Denmark
How do proinsulin peptides become immunogenic?

Christien Merrifield: Institute for Integrative Cell Biology - Gif sur Yvette, France
High resolution, real time imaging of GLP-1R endocytosis and signalling in living cells

Guadalupe Sabio: CNIC - Madrid, Spain
The key role of muscle in obesity-induced diabetes: a new function for p38 family

Anja Zeigerer: Hemholtz Center Munich - Germany
Defining a novel role of distinct membrane trafficking regulators in blood glucose control

2015

Henning Beck-Nielsen: Odense University Hospital - Denmark
Differentially methylated regions in offspring born to mothers with type 1 diabetes - consequences of the intrauterine milieu and implications for the phenotype? - the EPICOM study

Daniel Cunha: Free University of Brussels - Belgium
Thrombospondin 1 as a new target to boost beta cell survival in diabetes

Eran Elinav: Weizmann Institute of Science - Rehovot, Israel
The role of adipose inflammasomes in steady state and in obesity and type 2 diabetes

Josep Jimenez: Chillaron: University of Barcelona - Spain
Molecular determinants that link neonatal nutrition with late onset diabetes: epigenetic regulation of the circadian clock

Philippe Lefebvre: University of Lille - France
Epigenomic basis of metabolic memory

Charlotte Ling: Lund University - Malmö, Sweden
Epigenetic biomarkers for prediction of vascular complications and response to treatment in subjects with diabetes

Nico Mitro: University of Milan - Italy
Unravelling the role of the novel mitochondrial regulator/RNA binding protein Zc3h10 in diabetes

Matthew Poy: Max Delbrueck Center for Molecular Medicine - Berlin, Germany
Characterisation of phosphatidylinositol transfer protein alpha (PITPNA) in regulating pancreatic beta cell function

Petter Storm: Lund University Diabetes Center - Malmö, Sweden
Prediction of early diabetic complications using genetic and non-genetic factors - the ANDIS project

2014

Nabil Djouder: Spanish National Cancer Research Centre - Madrid, Spain
Growth factors and nutrients in type 2 diabetes: role of URI in beta cell plasticity and glucose homeostasis

Michelangelo Foti: University of Geneva - Switzerland
MicroRNA-dependent regulation of hepatokines affecting peripheral insulin sensitivity and adiposity

Shahram Hedjazifar: Lundberg Laboratory for Diabetes Research - Sweden
WISP2 and BMP4 exert regulatory effects on brown/beige fat cell formation- a potential therapeutic approach

Marju Orho-Melander: Lund University - Malmö, Sweden
Role of diet, genetic risk factors and microbiota in type 2 diabetes and cardiometabolic disease

Romano Regazzi: University of Lausanne - Switzerland
Role of PIWI-associated RNAs in the control of beta cell functions and in the development of diabetes

Romeo Ricci: IGBMC- Illkirch-Graffenstaden, France
Starvation-induced nascent insulin granule degradation: a new paradigm in pancreatic beta cell function

Mikael Rydén: Karolinska Institute- Stockholm, Sweden
A translational approach to identify novel regulators of insulin sensitivity in human adipose tissue

Emmanuel Van Obberghen: University of Nice - France
Potential protective role of brown adipose tissue in foetal programming of type 2 diabetes

2013

Julien Diana: St Vincent de Paul Hospital - Paris, France
Antimicrobial peptides: new players in the pathogenesis of type 1 diabetes?

Hèléne Duez: University of Lille - France
Role of skeletal muscle rev-erb-α   in glucose metabolism and insulin signalling

Kathrin Maedler: University of Bremen -  Germany
Targeting MST1 for treatment of type 2 diabetes

Margit Mahlapuu: University of Gothenburg - Sweden
Molecular mechanisms of insulin resistance in peripheral metabolic tissues

Anna Novials: IDIBAPS - Barcelona, Spain
Circulating exosomal mrRNAs as potential biomarkers and mediators of tissue cross-talk in diabetes

Cesare Patrone: Karolinska Institute - Stockholm, Sweden
Exendin-4 for the treatment of stroke in diabetes: from the preclinical to the clinical phase

Adam Rose: German Cancer Research Center - Heidelberg, Germany
Altering systemic protein/amino acid balance as a novel prophylactic strategy for type 2 diabetes

Allan Vaag: Copenhagen University Hospital - Denmark
Muscle and fat stem cell epigenetics and function in developmental programming of type 2 diabetes

2012

Massimo Federici: University of Rome - Italy
TIMP3 modulates immune cell microenvironment in a model of metabolic disease 

Philippe Gual: Archimed University - Nice, France
Regulation of adipose tissue dendritic cells and Th17 response by osteopontin/CD44 in diabetes and NAFLD 

Eric Kalkhoven: University Medical Center - Utrecht, The Netherlands
Adipocyte-iNKT cell cross-talk in lipid and glucose metabolism 

Nils Lycke: University of Gothenburg - Sweden
Mechanistic studies of a novel mucosal tolerance-inducing molecule that prevents type 1 diabetes 

Susanne Mandrup: University of Southern Denmark - Odense, Denmark
Genome-wide investigation of transcriptional networks regulated by glucose in pancreatic beta cells 

Esther Phielix: Maastricht University Medical Centre - The Netherlands
The role of altered dietary branched-chain amino acids supply in energy metabolism in relation to type 2 diabetes 

Patrik Rorsman: University of Oxford - UK
Insulin prevents counter-regulatory glucagon secretion by stimulation of somatostatin secretion 

Vera Schrauwen-Hinderling: Maastricht University - Medical Centre - The Netherlands
Preservation of metabolic flexibility by acetylcarnitine formation 

Emmanuel Van Obberghen: University of Nice - France
Alterations in pancreatic endothelial cells leading to beta cell failure and type 2 diabetes: role of glycated products and transient hyperglycaemia

2011

Peter Arner: Karolinska Institute - Stockholm, Sweden 
Studies on human fat cells which convey diabetes risk 

Mirielle Cormont: University of Nice - France
Role of MiR-34a in adipocyte insulin resistance 

Mirela Delibegovic: University of Aberdeen - UK
Consequences of macrophage PTB1B deletion on glucose and lipid maintenance, inflammation and tissue morphology 

Helene Duez: University of Lille - France
Role of Rev-erba in the control of oxidative metabolism and energy homeostasis in skeletal muscle 

Anthony Gavalas: Academy of Athens - Greece
Identification of novel signal receptors for the conversion of human stem cells in beta cells 

Eran Hornstein: Weizmann Institute of Science -Rehovot, Israel
Pancreatic microRNA-7 controls endocrine cell differentiation by regulating Pax6 expression 

Joel Le Moult: St Louis Hospital - Paris, France
HLA-G-mediated protection of islets against immune damage: physiology and therapeutic use for type 1 diabetes 

Carles Lerin: IDIBAPS - Barcelona, Spain
Unravelling novel molecular mechanisms underlying the development of insulin resistance 

Stefan Trapp: Imperial College London - UK
Molecular mechanisms and circadian regulation of glucose sensing in central GLP-1 neurons

2010

Anna Akhmanova: Erasmus Medical Centre - Rotterdam, The Netherlands
The role of ELKS in extracellular matrix-stimulated insulin secretion and survival of beta cells 

Philippe Froguel: Pasteur Institute of Lille, France
Search for novel aetiologies of unexplained MODY by using next generation sequencing of the whole exome

Stephan Herzig: German Cancer Research Center - Heidelberg, Germany
Transcriptional co-factors in BRITE adipocyte recruitment: implications for metabolism in type 2 diabetes

Richard Ijzerman: Free University Medical Center, The Netherlands
The time-course of cognitive functioning and cerebral structure and functions in type 1 diabetes mellitus with and without microangiopathy

Sander Kersten: Wageningen University, The Netherlands
The complement pathway and development of type 2 diabetes: the role of mannose binding lectin

Margit Mahlapuu: Gothenburg University, Sweden
Regulation of metabolic and inflammatory balance in liver and skeletal muscle by AMP-activated protein kinase

Suzanne Mandrup: University of Southern Denmark - Odense, Denmark
Genome-wide chromatin and transcriptional effects of metabolic stress in pancreatic beta cells

Hindrik Mulder: Lund University - Malmö, Sweden
Transcription factor B1 mitochondrial in beta cells and type 2 diabetes

José Ribeiro Bessa: University Pablo de Olavide - Seville, Spain
Dissecting the pancreas genetic networks using a novel enhancer disruption screen in zebrafish

Roy Taylor: Newcastle University, UK
Physiological changes in pancreas and liver during reversal of type 2 diabetes

Emmanuel Van Obberghen: University of Nice, France
Predisposition to beta cell failure and diabetes in progeny exposed to prenatal protein restriction: role of microRNAs

2009

Hadi Al-Hasani: German Institute for Human Nutrition Potsdam-Rehbruecke - Nuthetal, Germany 
Role of TBC1D1 in GLUT4 translocation 

Miriam Cnop: Free University Brussels, Belgium
Stress relief or anti-apoptotic defense? Mechanisms of GLP-1 protection against lipotoxic endoplasmic reticulum stress in pancreatic beta cells 

Yuval Dor: Hebrew University of Jerusalem, Israel
Control of pancreatic cell specification by Groucho/TLE-mediated transcriptional repression 

Sylvie Guerder: Physiopathology Centre of Toulouse-Purpan, France
Study of the function of the protease TSSP, a protease that controls diabetogenic CD4 T cell development and autoimmune diabetes in the NOD mouse 

Per-Anders Jansson: Sahlgrenska University Hospital - Gothenburg, Sweden
Muscle insulin resistance - from molecular mechanisms to lifestyle intervention

Daniel Konrad: University Children's Hospital - Zurich, Switzerland
Regulation of glucose and energy homeostasis by fat tissue transplantation 

Anna Krook: Karolinska Institutet - Stockholm, Sweden
Skeletal muscle molecular mechanisms mediating exercise benefits in type 2 diabetes mellitus 

Charlotte Ling: Lund University - Malmö, Sweden
Impact of genetic and epigenetic factors on type 2 diabetes

Margit Mahlapuu: Lundberg Laboratory - Gothenburg, Sweden
Regulation of metabolic and inflammatory balance in liver and skeletal muscle by AMP-activated protein kinase

Michael Roden: Heinrich-Heine University - Düsseldorf, Germany
Insulin resistance of mitochondria and the effect of insulin therapy in humans 

Yakup Tanriver: University Hospital Freiburg - Germany
Redirecting naturally occurring regulatory T cells with chimeric antigen receptors to induce transplantation tolerance against pancreatic islet grafts

2008

Peter Carmeliet: Flanders Institute for Biotechnology - Zwijnaarde, Belgium
Evaluation of the oxygen sensor prolyl 1 hydroxylase domain 1 (PHD1) protein as a novel anti-type 2 diabetic target 

Miriam Cnop: Free University Brussels - Belgium
Mitochondrial dysfunction in insulin resistance and pancreatic beta cell failure - role in the pathogenesis of diabetes in Friedreich's ataxia

Stephan Herzig: Deutsches Krebsforschungszentrum Heidelberg - Germany
Hepatic inflammation through co-activator-dependent macrophage activation in obesity-related type 2 diabetes

Claes Wollheim: University of Geneva - Switzerland
Intervention studies to ameliorate ER stress in diabetes using animal and cell models of MODY3

2007

Francesco Beguinot: University of Naples - Italy
Prep1(pKnox) gene function in type 2 diabetes 

Ingo Leibiger: Karolinska Institutet - Sweden
Non-invasive in vivo imaging of pancreatic beta cell signal-transduction

Martine Vaxillaire: Institut Pasteur Lille - France
Post genome-wide association study and functional investigation of novel type 2 diabetes susceptibility genes (GWAFI-T2D)

Juleen Zierath: Karolinska Institutet - Sweden
Epigenetic modifications involved in insulin sensitivity in human skeletal muscle

2006

Angelo Avogaro: University of Padova - Italy
The protein p66Shc and the alterations of endothelial progenitor cells in diabetes 

Benoit Gauthier: University Medical Center - Geneva, Switzerland
Human blood monocytes as a source of surrogate beta cells for cellular therapy of type 1 diabetes; establishment of an optimal and reproducible protocol

Joanne Rasschaert: Brussels Free University - Belgium
The signal transduction of virus-induced beta cell death and insulitis

Michele Solimena: Dresden University of Technology - Germany
SUMOylation in beta cells

2005

Jens Brüning: Cologne University - Germany
Role of insulin action in hypothalamic AgRP/NPY-expressing neurons in the regulation of energy homeostasis and gluconeogenesis 

Sarah Ferber: Sheba Medical Center - Tel-Hashomer, Israel
Improving the therapeutic outcome of using liver to replace pancreatic b-cells function in adult human tissues

Patrick Schrauwen: Maastricht University - The Netherlands
Cardiac lipid content and energy status in type 2 diabetes mellitus

Peter Van Endert: Paris Necker Institute - France
Prediction and treatment of type 1 diabetes by CD8+ T cell islet epitopes in HLA-A2/NOD mice

2004

Giovanni Camussi: Turin University - Italy
Role of monocyte chemoattractant protein-1 in diabetic nephropathy 

Jorge Ferrer: Institute for Biomedical Research - Barcelona, Spain
A genetic model to study multipotent progenitors of the embryonic and adult pancreas

Concepción Mora Giral: Institute for Biomedical Research - Barcelona, Spain
Study of the immunological balance resulting from pancreating beta cell hyperplasia and autoaggressive lymphocytic invasion in the NOD/Cdk4R24C knockin mice. Tumor immunity in NOD (Non Obese Diabetic) Autoimmune-pronemurine model

Giorgio Sesti: Magna Graecia University - Catanzaro, Italy
Elucidation of the molecular mechanisms by which pro- and anti-infammatory molecules affect insulin signalling related to glucose metabolism in skeletal muscle cells and adipocytes

Nils Welsh: Uppsala University - Sweden
c-Abl, a mediator of beta-cell death?

2003

Angelika Bierhaus: Heidelberg University - Germany
RAGE-dependent NF-κβ activation in the pathogenesis of diabetic neuropathy 

Monica Montagnani: Bari University - Italy
Elucidation of adiponectin signalling pathways related to activation of endothelial nitric oxide synthase in the vasculature

Juleen Zierath: Karolinska Institute - Stockholm, Sweden
The role of Diacylglycerol Kinase Delta (DGKd) in the regulation of glucose homeostasis: novel signalling pathways involved in insulin resistance in type 2 diabetes mellitus